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Tag: blindness

Can we really put an implant inside the eye to deliver drugs to treat eye diseases?

TeachableMedicalNews article 06152022

Teachable moment in classrooms:

  1. cellular basis of life chapter – diffusion as a means of molecular movement
  2. special senses chapter – the photoreceptors rods and cones are in the retina
  3. special senses chapter – liquid-filled chambers of the eye
  4. special senses chapter – sclera, the white of the eye, is the toughest, outer layer

Can we put an implant inside the eye to deliver drugs to treat eye diseases?

The news item:  Recently a report appeared about a drug, Susvimo, that reverses blindness:

New technology helps Georgetown veteran restore his eyesight

If you’re living with blurry vision, there’s a chance a new device can help you get your eyesight back without frequent visits to the doctor. The newly FDA-approved Susvimo implant helped one Georgetown veteran preserve his vision after being diagnosed with wet age-related macular degeneration.

The article states that AMD (wet, age-related macular degeneration) is the leading cause of blindness over the age 60, that this disorder is caused by growth and scarring of blood vessels under the retina, and that drug-delivery through an implant has restored vision in 90% of the treated individuals.

So, Why Do I Care??  Eye diseases can rob people of their vision. Many of such diseases are treated by injection of a drug into the eye. It is estimated that there are over 10 million such injections per year in the USA. Because chronic eye disorders require several injections into the same eye, it is worth exploring alternative delivery systems for long-term administration of drugs.

Plain English, Please!!!   First, let’s review the action of Susvimo, the drug we will use as an example to learn about implants inside the eye. In a previous post of Teachable Medical News (TMN 05252022), we described the action of the drug Susvimo. Here is a brief summary:  Normally the light-sensing cell in the

What makes some hand sanitizers dangerously toxic?

TeachableMedicalNews article 08282020

Teachable moment in classrooms:

  1. chemical basis of life chapter – adenosine triphosphate (ATP)
  2. cellular basis of life chapter –sites of detoxification inside the cell
  3. cellular basis of life chapter – mitochondria as site of ATP production
  4. digestive system chapter – absorption through stomach mucosa
  5. metabolism chapter – electron transport chain as most efficient ATP producing process inside mitochondria
  6. special senses chapter – gross anatomy of optic nerve

The news item:  A recent news item described over a hundred hand sanitizer brands are being removed from store shelves because they may be dangerously toxic:

FDA says to avoid these 130 hand sanitizer products that may not work, or are toxic

Regulators say some of the products contain dangerous levels of methanol, which can lead to blindness, hospitalization and even death.

The article mentions that the toxic ingredient is methanol, and that it may cause blindness.

So, Why Do I Care??  Poisoning by methanol, also called wood alcohol, sickens over 20,000 people each year in the US.  These people may become blind in 24 hours, and suffer long-lasting damage to their kidneys and brain. The best prevention is not to consume methanol either by drinking or through contact with skin, such as through hand sanitizers.  So, taking hand sanitizers off the shelf is part of the prevention.

Plain English, Please!!! First, let’s talk about what methanol is. Methanol is chemically similar to ethanol, the alcohol in adult beverages. Methanol gets into hand sanitizers when the ethanol ingredient is contaminated with methanol. When ethanol is made by distilleries, sometimes inadvertently methanol is distilled into the product, so then it becomes part of the hand sanitizer.

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