TEACHABLE MEDICAL NEWS

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Month: April 2020

How could the leukemia fighter drug Calquence help us defeat the SARS-CoV-2 coronavirus?

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On April 24, 2020

In cardiovascular system, lymphatic and immune system, respiratory system

TeachableMedicalNews article 04242020

Teachable moment in classrooms:

  1. blood chapter – white blood cell types and their functions
  2. blood chapter – malfunctioning mechanisms in leukemia
  3. respiratory system chapter – alveoli as the sites of gas exchange
  4. respiratory system chapter – immune defense cells of alveoli
  5. lymphatic and immune system chapter – events of inflammation

How could the leukemia fighter drug Calquence help us defeat the SARS-CoV-2 coronavirus?

The news item:  Recent articles reported that the anti-cancer drug will be evaluated as potential treatment of SARS-CoV-2 infected patients:

AstraZeneca to test impact of cancer drug Calquence on coronavirus patients

Calquence (acalabrutinib) belongs to a class of drugs called Bruton’s tyrosine kinase (BTK) inhibitors which can suppress autoimmune diseases. The drug, which is currently used to treat certain types of blood cancers, has already been approved for the treatment of adult patients with chronic lymphocytic leukaemia in the U.S.

The news item mentions cytokine storm in coronavirus infected patients, and that the drug is a BTK inhibitor.

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How could the antiviral drug remdesivir help us defeat the SARS-CoV-2 coronavirus?

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On April 19, 2020

In cellular basis of life, chemical basis of life, respiratory system

TeachableMedicalNews article 04182020

Teachable moment in classrooms:

  1. chemical basis of life chapter – nucleotides that make up RNA
  2. cellular basis of life chapter – RNA production for cellular uses
  3. microbiology – corona viruses are RNA viruses

The news item:  A recent article discussed clinical trial results of the drug remdesivir:

Report: Covid-19 patients recovering quickly after getting experimental drug | CNN

Covid-19 patients who are getting an experimental drug called remdesivir have been recovering quickly, with most going home in days, STAT News reported Thursday after it obtained a video of a conversation about the trial.

The news item mentions promising anecdotal information of the drug, and that it was found effective in animals against other coronavirus-based diseases.

So, Why Do I Care??  Have you been living under a rock in the last few

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Can we treat sickle cell anemia by making red blood cells less sticky?

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On April 1, 2020

In cardiovascular system, cellular basis of life

TeachableMedicalNews article  04012020

Teachable moment in classrooms:

  1. cellular basis of life chapter – concept of one gene, one protein
  2. cellular basis of life chapter – concept of gene mutation leading to protein malfunction
  3. cellular basis of life chapter – adhesion proteins in plasma membrane
  4. blood chapter – red blood cell structure
  5. blood chapter – sickle cell anemia caused by globin gene mutation

The news item:  Recently a new drug, Adakveo, was approved to treat sickle cell anemia patients:

https://www.cnbc.com/2019/12/20/novartis-wins-medicaid-approval-for-new-sickle-cell-drug-in-key-us-states.html

The article mentions that this disorder afflicts 100,000 people in the USA, that the disorder is caused by sickle shaped red blood cell, that the drug is a biological and injectable drug, and that the drug treats the pain crises of this disorder.

So, Why Do I Care??  There are millions of people living with this disease

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